Kozyrev (masculine, ) or Kozyreva (feminine, ) is a Russian surname. Notable people with the surname include:
Andrey Kozyrev (born 1951), Russian politician Lyubov Kozyreva (disambiguation), multiple people Nikolai Aleksandrovich Kozyrev (1908-1983), Soviet astronomer and astrophysicist Nikolai Ivanovich Kozyrev (1934-2021), Soviet and Russian diplomat Yuri Kozyrev (born 1963), Russian photojournalist Stanislav Kozyrev (born 1987), Russian footballer
See also 2536 Kozyrev, main-belt asteroid Kozyrev (crater), lunar crater