Esterhuysen may refer to:
People Anriette Esterhuysen (born 1953), South African computer networking pioneer and human rights defender Elsie Elizabeth Esterhuysen (1912–2006), South African botanist Richard Grant Esterhuysen, real name of Richard E. Grant (born 1957), British-Swazi actor
Science Botany Esterhuysenia, genus of flowering plants belonging to the family Aizoaceae, named in honor of Elsie Elizabeth Esterhuysen
Astronomy 11694 Esterhuysen, minor planet
See also Francois Esterhuyzen (born 1994), South African rugby union player