Entwisle is a surname. Notable people with the surname include:
Gertrude Lilian Entwisle (1892–1961), British electrical engineer; Edmund Entwisle (1660–1707), English clergyman; Joseph Entwisle (1767–1841), English Methodist minister; Peter Entwisle (1948–2018), New Zealand art historian; Richard William Entwisle (born 1986), namesake of the minor planet 21522 Entwisle; Timothy John Entwisle (born 1965), Australian botanist; William Entwisle (1808–1865), British politician.
See also Bertine Entwisle Sutton (1886–1946), British pilot and Air Marshall Entwistle (disambiguation) Entwistle (surname)