MSFS may refer to:
Microsoft Flight Simulator, a series of flight simulator video games. Microsoft Flight Simulator (2024 video game), the 2024 edition of the series. Missionaries of St. Francis de Sales, a Catholic religious group
Graduate degrees Master of Science in Financial Services, such as from the American College of Financial Services, Bryn Mawr, Pennsylvania Master of Science in Foreign Service, in international affairs, such as from the Walsh School of Foreign Service, Georgetown University, Washington D.C. Master of Science in Forensic Science, such as from the John Jay College of Criminal Justice at City University of New York Master of Science in Financial Management and Information Systems, such as from the University of Maryland University College