Quain is a surname. Notable people with the surname include:
Buell Quain (1912–1939), American ethnologist Eric P. Quain (1870–1962), American physician Fannie Almara Quain (1874–1950), American family physician John Richard Quain (1816–1876), Irish barrister and judge Jones Quain (1796–1865), Irish anatomist Kevin Quain, Canadian musician Richard Quain (Irish physician) (1816–1898), Irish physician Richard Quain (1800–1887), English anatomist and surgeon
See also An Examination of the Work of Herbert Quain, a 1941 short story by Argentine writer Jorge Luis Borges Quain Professor, the professorship title for certain disciplines at University College, London, England