Mankiller may refer to:
Surname Mankiller, a family surname and traditional Cherokee military rank Wilma Mankiller, first female Chief of the Cherokee Nation Ostenaco (ca. 1703 – 1780), Cherokee mankiller often referred to by his rank
Media Man-Killer, a supervillain in the Marvel Comics universe Mankillers, also known as 12 Wild Women, a 1987 US film Mankiller (film), a 2017 film
See also Skiagusta – Cherokee military ranks