HPC may refer to:
Organisations Health Professions Council, a British regulator Hmar People's Convention, an Indian political party Ho-Ping Power Company, Taiwan Croatian Orthodox Church (; 1942–1945) Hydrometeorological Prediction Center, United States Afghan High Peace Council, Afghanistan
Science, technology and mathematics Hardware performance counters, in computers Hasty Pudding cipher, in cryptography Hemangiopericytoma, a cancerous tumour Heterotrophic Plate Count, in ecology High Power Charging, for electric vehicles High-performance computing HPC Challenge Benchmark Hilbert system, a formal proof system in logic Hilbert–Pólya conjecture, a conjecture in number theory History of presenting complaint, in a British medical history Hot potassium carbonate, a carbon scrubbing method for gases Hydroxypropyl cellulose, in organic chemistry and pharmacology Hematopoietic Progenitor Cell, a cell therapy
Other uses Hinkley Point C nuclear power station, England Hydraulic Press Channel, a Finnish YouTube channel HeartCatch PreCure!, an anime series (2010–2011), not to be confused with Hug! Pretty Cure (HuPC) Hi-Point carbine, a series of American guns Helios Pickleball Center, an under construction indoor pickleball complex in the Philippines
See also Windows HPC Server 2008, an operating system for high-performance computing by Microsoft