Plum Island may refer to:
Places Plum Island (Massachusetts), an island in Essex County, Massachusetts Plum Island Airport, in Newburyport, Massachusetts Plum Island (New York), an island near Long Island, New York Plum Island Animal Disease Center, a United States federal research facility dedicated to the study of animal diseases that is located on Plum Island, New York Plum Island Light also known as Plum Gut Light, a lighthouse located on Plum Island, New York Plum Island (Wisconsin), an island in Washington Township, Door County, Wisconsin Plum Island Range Lights, a pair of range lights located on Plum Island in Door County, Wisconsin Plum Island Bald Eagle Refuge, a 52-acre island in the Illinois River Plum Island Site, Native American archaeological site in Illinois
Art, entertainment, and media Plum Island (novel), a 1997 novel by Long Island author Nelson DeMille Plum Island (Survival of the Dead), fictional island "Plum Island", a song by the band Waterparks from the album Double Dare "Plum Island", a song by music group The Orb from the album Cydonia
See also Plummers Island, in Montgomery County, Maryland