NKX-homeodomain factors are a family of homeodomain transcription factors that are critical regulators of organ development.

Human genes that encode NKX-homeodomain factors include:

NKX1-1, NKX1-2 NKX2-1, NKX2-2, NKX2-4, NKX2-8 NKX3-1, NKX3-2 NKX6-1, NKX6-2, NKX6-3

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