Chymotrypsin-C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene. This enzyme is primarily produced in the pancreas by acinar cells, where it is involved in regulating the activation of digestive enzymes like trypsins and carboxypeptidases.
Function
Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. In other words, it is involved in breaking peptide bonds in proteins. It catalyzes the preferential cleavage of peptide bonds from the following amino acids: Leu┼, Tyr┼, Phe┼, Met┼, Trp┼, Gln┼, Asn┼
This is enzyme activity is similar to chymotrypsin A/B (), but with some differences such as a preference for breaking leucine over phenylalanine bonds.
A protein with similar enzyme activity can also be formed from pig chymotrypsinogen C and cattle subunit II of procarboxypeptidase A.
See also Acinar cell
References
Further reading