The R22 is a provincial route in the KwaZulu-Natal province of South Africa, connecting the N2 at Hluhluwe with the Mozambique border at Kosi Bay, via Mbazwana and Kwangwanase. It was opened on 25 October 2008.
Route The R22 begins at an intersection with the N2 national route west of Hluhluwe. It begins by heading eastwards into Hluhluwe before making a left and right turn to bypass the Hluhluwe River mouth on Lake St. Lucia and continue northwards. It heads for to reach the village of Mduku east of the Phinda Private Game Reserve and west of the ISimangaliso Wetland Park. It continues for , crossing the Mkuze River, to reach Mbazwana (west of Sodwana Bay and the Sodwana Bay National Park).
It continues for , bypassing Lake Sibaya in the Maputaland, to reach a roundabout in Phelandaba, where it turns to the north-east. It heads for to reach the town of KwaNgwanase (also known as Manguzi and Kosi Bay Town) before heading another (bypassing the Kosi Bay lakes) to reach the Kosi Bay border with Mozambique. It becomes the N200 road on the Mozambique side of the border and connects to Maputo (capital of Mozambique; away). The border on the Mozambique side is named Ponta do Ouro.
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