The 2010 New Mexico Lobos football team represented the University of New Mexico as a member of the Mountain West Conference (MW) during the 2010 NCAA Division I FBS football season. Led by second-year head coach Mike Locksley, the Lobos compiled an overall record of 1–11 with a mark of 1–7 in conference play, tying for eighth place at the bottom of the MW standings. The team played home games at University Stadium in Albuquerque, New Mexico.
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