Upson House may refer to:
in the United States (by state) Hubbard-Upson House, Sacramento, California, listed on the National Register of Historic Places in Sacramento County, California Upson House (Athens, Georgia), listed on the National Register of Historic Places in Clarke County, Georgia Pearl Upson House, Reno, Nevada, listed on the National Register of Historic Places in Washoe County, Nevada Upson House (Mansfield, Ohio), listed on the National Register of Historic Places in Richland County, Ohio