The abbreviations CH5, Ch5, and variations thereof may mean:

, the chemical formula of methanium, an organic ion CH5 Deeside, part of the CH postcode area, Great Britain Bacteriocin CH5, an antibacterial produced by Lactobacillus acidophilus Chile Route 5, a highway in Chile CH5, a type of cirrus cloud Channel 5 (disambiguation), a common name of television networks, channels and stations around the world 22291 Heitifer (1989 CH5), a main-belt asteroid