Pendleton House may refer to:

in the United States (by state then city) William Kimbrough Pendleton House, Eustis, Florida, listed on the NRHP in Lake County Col. Edmund Pendleton House, Clintonville, Kentucky, listed on the NRHP in Clark County Pendleton House (Falmouth, Kentucky), listed on the NRHP in Pendleton County Pendleton House (Hartford, Kentucky), listed on the NRHP in Ohio County James G. Pendleton House, Searsport, Maine, listed on the NRHP in Waldo County Pendleton Ruin, Animas, New Mexico, listed on the NRHP in Hidalgo County George Hunt Pendleton House, Cincinnati, Ohio, listed on the NRHP