Amphilestidae is a family of Mesozoic mammals, generally regarded as eutriconodonts. They may form a paraphyletic or polyphyletic assemblage, though they share with gobiconodontids their similar tooth occlusion patterns and may be especially closely related to them.Percy M. Butler; Denise Sigogneau-Russell (2016). "Diversity of triconodonts in the Middle Jurassic of Great Britain" (PDF). Palaeontologia Polonica 67: 35–65. . They occur from the Middle Jurassic to Cenomanian,Jerry J. Hooker and Allan G. Lawson, 2011. A ‘eutriconodontan’ mammal from the UK Cenomanian (Late Cretaceous), Publication: Special Papers in Palaeontology 86: 255–261 and have a distribution across Laurasia.
The putative amphilestid Tendagurodon is considered a non-amphilestid member of Amphilestheria along with the newly described Condorodon by Gaetano and Rougier (2012).L. C. Gaetano and G. W. Rougier. 2012. First amphilestid from South America: a molariform from the Jurassic Cañadón Asfalto Formation, Patagonia, Argentina. Journal of Mammalian Evolution
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