Humphreys House or Humphreys Building may refer to:
in the United States David C. Humphreys House, Huntsville, Alabama, listed on the National Register of Historic Places (NRHP) Humphreys-Ryan House, Hot Springs, Arkansas, NRHP-listed, in Garland County Gen. David Humphreys House, Ansonia, Connecticut, NRHP-listed in New Haven County Sanford-Humphreys House, Seymour, Connecticut, listed on the NRHP in New Haven County, Connecticut Sir John Humphreys House, Swampscott, Massachusetts, NRHP-listed Rosemary-Humphreys House, Greenwood, Mississippi, listed on the NRHP in Leflore County, Mississippi Humphreys Drugstore Building, Grandfield, Oklahoma, listed on the NRHP in Tillman County, Oklahoma
See also Humphrey House (disambiguation)