Van Mierlo is a Dutch toponymic surname, meaning "from Mierlo". People with this surname include:
Godfried van Mierlo (1518–1587), Dutch Dominican Bishop of Haarlem and Abbot of Egmond Hans van Mierlo (1931–2010), Dutch politician and journalist, minister of Defence, minister of Foreign Affairs and Deputy Prime Minister Toine van Mierlo (1957), Dutch footballer Freddie van Mierlo (1989/1990), British politician