Lefrançois or LeFrançois () is a surname of French origin. Notable people with the surname include:
Anne-Marie LeFrançois (born 1977), Canadian skier Cathy LeFrançois (born 1971), Canadian professional bodybuilder Charles Lefrançois (born 1972), Canadian Olympic high jumper J.-Eugène Lefrançois (1896–1979), Québécois industrialist and politician Laurent Lefrançois (born 1974), French composer Marc LeFrançois (born 1939), Canadian business executive; former president and CEO of Via Rail Canada Nicolas Lefrançois (1794–1866), Canadian surveyor Nicolas Lefrançois (cyclist) (born 1987), French cyclist Roselyne Lefrançois (born 1950), French politician Sabrina Lefrançois (born 1980), French Olympic figure skater
See also Gustave Lefrançais (1826–1901), French revolutionary