Grayson House may refer to:
Grayson House (Fort Necessity, Louisiana), listed on the National Register of Historic Places in Franklin Parish, Louisiana Grayson House (Monroe, Louisiana), listed on the National Register of Historic Places in Ouachita Parish, Louisiana Dr. C. S. Grayson House, High Point, North Carolina, listed on the National Register of Historic Places in Guilford County, North Carolina John Grayson House, Graysontown, Virginia, NRHP-listed Grayson-Gravely House, Graysontown, Virginia, NRHP-listed