Keystone Hotel may refer to:
Keystone Hotel (Castle Rock, Colorado), listed on the National Register of Historic Places in Douglas County, Colorado Keystone Hotel (Hummelstown, Pennsylvania), listed on the National Register of Historic Places in Dauphin County, Pennsylvania Keystone Hotel (Lampasas, Texas), Recorded Texas Historic Landmark Keystone Hotel (McCook, Nebraska), listed on the National Register of Historic Places in Red Willow County, Nebraska Keystone Hotel (film), a 1935 short film directed by Ralph Staub