John Johnston House may refer to:
John Johnston House (Sault Ste. Marie, Michigan), listed on the National Register of Historic Places (NRHP) John S. Johnston House, Missoula, Montana, listed on the NRHP in Missoula County, Montana John Johnston House (Yanceyville, North Carolina), listed on the NRHP in Caswell County, North Carolina
See also John H. Johnston Cotton Gin Historic District, Levesque, Arkansas, listed on the National Register of Historic Places in Cross County, Arkansas Johnston House (disambiguation)