Jamestown Historic District may refer to:
Jamestown Historic District (Jamestown, North Carolina), listed on the National Register of Historic Places in Guilford County, North Carolina Jamestown Historic District (Jamestown, North Dakota), listed on the National Register of Historic Places in Stutsman County, North Dakota Jamestown Historic District (Florence, South Carolina), listed on the National Register of Historic Places in Florence County, South Carolina Jamestown Downtown Historic District, Jamestown, New York