Grimes House may refer to:
in the United States (by state then city) Grimes House (Manhattan, Kansas), listed on the National Register of Historic Places (NRHP) in Riley County Grimes House (Smith Center, Kansas), NRHP-listed in Smith County Willis Grimes House, Danville, Kentucky, NRHP-listed in Boyle County Felix Grimes House, Owensboro, Kentucky, NRHP-listed in Daviess County Grimes House and Mill Complex, Lexington, Kentucky, NRHP-listed in Fayette County Jonathan Taylor Grimes House, Edina, Minnesota, NRHP-listed Grimes Homestead (Mountain Lakes, New Jersey), NRHP-listed Dr. C. A. Grimes House, Bastrop, Texas, NRHP-listed in Bastrop County Grimes House (Hillsboro, Texas), NRHP-listed in Hill County