Sprague House may refer to:

in the United States (by state then city) Lillard-Sprague House, Rogers, Arkansas, listed on the National Register of Historic Places (NRHP) in Benton County Elias Sprague House, Coventry, Connecticut, listed on the NRHP in Tolland County Sprague Street Houses, Shreveport, Louisiana, listed on the NRHP in Caddo Parish Sprague House (Danvers, Massachusetts), listed on the NRHP in Essex County Thomas S. Sprague House, Detroit, Michigan, listed on the NRHP in Detroit Rollin Sprague Building-Old Stone Store, Rochester, Michigan, listed on the NRHP in Oakland County David R. and Ellsworth A. Sprague Houses, Caledonia, Minnesota, listed on the NRHP in Houston County Sprague House, Ithaca, New York Sprague-Deaver House, Fredericktown, Ohio, listed on the NRHP in Knox County Jonathan Sprague House, Lowell, Ohio, listed on the NRHP in Washington County Sprague House (Wellington, Ohio), listed on the National Register of Historic Places in Lorain County Sprague-Marshall-Bowie House, Portland, Oregon, listed on the NRHP in Northwest Portland Gov. William Sprague Mansion, Cranston, Rhode Island, listed on the NRHP in Providence County David Sprague House, Providence, Rhode Island, listed on the NRHP in Providence County