Svetlana Kuznetsova defeated Maria Sharapova in the final, 6–4, 6–3 to win the women's singles tennis title at the 2006 Miami Open. It was her first Tier I title and sixth overall, and her first title of any kind since September 2004.

Kim Clijsters was the defending champion, but lost in the second round to Jill Craybas.

Seeds All seeds received a bye into the second round.

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8

External links Main and Qualifying Draw