Andy Roddick defeated Tomáš Berdych in the final, 7–5, 6–4 to win the men's singles tennis title at the 2010 Miami Open. It was his first Masters title since 2006, and his second career Miami Open title.
Andy Murray was the defending champion, but lost to Mardy Fish in the second round.
Seeds All seeds receive a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Section 3
Section 4
Bottom half
Section 5
Section 6
Section 7
Section 8
Qualifying
Seeds
Qualifiers
Lucky losers
Draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
Eighth qualifier
Ninth qualifier
Tenth qualifier
Eleventh qualifier
Twelfth qualifier
External links Main Draw Qualifying Draw