O'Toole is a surname of Irish origin. It is an anglicized form of the Gaelic Ó Tuathail meaning "descendant of Tuathal", composed of tuath "the people" and gal "mighty". The O'Toole family were a leading clan in Gaelic Leinster and Ulster.

Notable people Adam Dubh Ó Tuathail, Irish heretic, executed 1328 Annette O'Toole (b. 1952), American dancer and actress Anton O'Toole, Irish footballer Chauncey O'Toole (b. 1986), Canadian rugby player Donald L. O'Toole (1902–1964), American politician from New York Edmund O'Toole, soldier won the Victoria Cross in the Anglo-Zulu war Erin O'Toole (b. 1973), Canadian politician Fintan O'Toole (b. 1958), columnist and drama critic for The Irish Times Gary O'Toole, Irish Olympic Swimmer James O'Toole (American politician) (b. 1958) James O'Toole (disambiguation), several people Jim O'Toole. American baseball player Joe O'Toole, Irish politician John O'Toole, politician in Ontario, Canada John-Joe O'Toole (b. 1988), Irish footballer Kathleen O'Toole (b. 1954), former police commissioner of Boston, Massachusetts Kevin F. O'Toole (1950), American lawyer, attorney and gaming regulator Kevin J. O'Toole (b. 1964), American Republican Party politician Kevin O'Toole (bodybuilder), Canadian bodybuilder and mixed martial artist Lorcán Ua Tuathail (1128–1180), Archbishop of Dublin and Saint Mark O'Toole (disambiguation), several people Matt O'Toole, TV actor Maureen O'Toole (b. 1961), American water polo player and coach Mick O'Toole (1931–2018), Irish racehorse trainer Mor Ui Thuathail (c. 1114–1191), Queen of Leinster Muirchertach Ua Tuathail (fl. 1114) King of Ui Muirdeaigh, father-in-law of Diarmait Mac Murchada Paddy O'Toole (1938–2025), Irish politician Pat O'Toole, Canadian lacrosse player Peter O'Toole (1932–2013), Irish actor Randal O'Toole, American economist and public policy expert Rich O'Toole, American singer-songwriter Tara O'Toole Under Secretary of Homeland Security for Science and Technology 2009-2013 Tom O'Toole (disambiguation), several people

Fictional characters Plenty O'Toole, in the 1971 James Bond film Diamonds Are Forever JD O'Toole, in Grand Theft Auto: Liberty City Stories Michael O'Toole, in Arthur C. Clarke and Gentry Lee's novels Rama II, The Garden of Rama, and Rama Revealed Timmy O'Toole, a fictional character created by Bart Simpson in his practical joke involving a walkie-talkie at the bottom of a well, in The Simpsons episode "Radio Bart". Sneakers O'Toole, who appears briefly in Family Guy episode "Boys Do Cry".

See also Tohill Toal (disambiguation) O'Toole (disambiguation)