A borderline tumor, sometimes called low malignant potential (LMP) tumor, is a distinct but yet heterogeneous group of tumors defined by their histopathology as atypical epithelial proliferation without stromal invasion. This topic last updated: Feb 08, 2019. It generally refers to such tumors in the ovary (generally specifically called borderline ovarian tumors (BOT)) but borderline tumors may rarely occur at other locations as well.
Borderline ovarian tumor Borderline ovarian tumours differ from epithelial ovarian cancer by their low incidence, frequent association with infertility, low association with mutations in BCRA genes, different percentages of the most common histological types, early stage diagnosis, and high survival rate, even when associated with peritoneal involvement. They occur in younger women, which is why one of the objectives in these patients will be the preservation of fertility. The management of these tumours has been widely discussed and still continues to be controversial. The latest findings underscore the importance of full staging in both radical and conservative surgery, to choose the most comprehensive treatment and obtain an accurate prognosis. One of the objectives of this article shall be the in-depth review of the indications, benefits, and disadvantages of each type of surgery, as well as the usefulness of the medical treatment. In addition, the article aims to review follow-up guidelines and to clarify the main prognostic factors that affect recurrence and survival of these patients.Originally copied from: -"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0)"
Borderline ovarian tumours (BOTs) have been qualified as low malignant potential tumours by the FIGO since 1971. They are classified within malignant epithelial ovarian tumours, constituting 10–20% of these.
Their incidence is low, and is calculated in European series at around 4.8/100,000 new cases per year and even lower in American series, between 1.5 and 2.5/100,000 cases per year.
They occur in women at approximately 40 years of age (in 27–36% of cases the tumours occur at a younger age), compared with an average occurrence at 60 years in the case of invasive carcinoma.
The risk and protective factors for the occurrence of BOT are similar to those of carcinoma; however, the association with mutations in BCRA genes is exceptional. In some studies, an increase in the incidence (two to four times greater) of serous BOT in women undergoing assisted reproduction techniques has been observed. This seems to have some correlation with the hormonal levels achieved during ovarian stimulation and the damage caused by repeated gonadal punctures.
Some patients with BOT (16–30%) are asymptomatic when diagnosed and the discovery is incidental; nevertheless, when there are symptoms these are often non-specific, similar to other adnexal tumours, such as pelvic pain or abdominal distension.
Classification Depending on their size, BOTs are classified according to the FIGO classification used for other ovarian tumours; however, the majority of these tumours (70–80%) are diagnosed at stage I, compared with 25% of carcinomas. A diagnosis of BOT in stages II and III is rare, and exceptional in stage IV.
Most of the BOTs, like carcinomas, are serous tumours, accounting for about 53–65%. Mucinous BOT constitutes between 32% and 42% of the total (compared with less than 10% of mucinous ovarian carcinomas). The rest of the BOTs (less than 5%) are composed of endometrial tumours, clear-cell tumours, Brenner's tumours, and other unique histologies.
Serous BOT
Tumours are bilateral in one-third of cases. These are associated with peritoneal implants in 35% of cases, of which up to 15–25% can be invasive implants, the omentum being the most common area affected. In addition, in advanced stages, these may be associated with lymphatic involvement in about 27% of cases, including the following in descending order of frequency: pelvic, omental and mesenteric, and paraaortic and supradiaphragmatic regions.
Serous BOT can be further divided into two subtypes:
– Typical pattern (90%) is often a unilocular cystic mass with fine septa in its interior.
– Micropapillary pattern (10%) presents specific histological features (micropapillary appearance contiguous over > 5mm or in more than 10% of the tumour). The latter has a worse prognosis since the majority are associated with a higher rate of recurrence in invasive form, a greater percentage of bilaterality and presence of invasive implants, and upstaging when performing restaging surgery. However, the latest publications suggest that serous BOT with micropapillary pattern and without implants (stage I) or with non-invasive implants (II and III) could have the same prognosis as serous BOT without micropapillary pattern. Therefore, malignancy is more closely related to the presence and invasiveness of implants.
Mucinous BOT These tend to be larger than serous BOT and have either a unilocular or multilocular cystic structure, with fine septa in their interior and intramural nodules. Peritoneal implants are very uncommon (15%), and when they occur, a mixed histology as well as the presence of pseudomyxoma peritonei must be ruled out. These are considered a differentiated entity, in which peritoneal involvement of a mucinous carcinoma is primarily of digestive origin, generally of the appendix.
They are divided into two subtypes:. Intestinal (85–90%): the majority of these are unilateral and in the case of a bilateral occurrence, primary intestinal cancer must be ruled out. Endocervical or Müllerian (10–15%): these are bilateral in at least 40% of cases and 20–30% are associated with ipsilateral endometriomas or pelvic endometriosis, as well as with BOT of mixed histology (seromucinous).
Diagnosis
Although the diagnosis of suspected BOT will be carried out using analytics, ultrasound, magnetic resonance imaging, and positron emission tomography (PET), as well as macroscopically, it is not possible to differentiate BOT from other ovarian tumours. The definitive diagnosis is histological. The histological criteria for diagnosis are: epithelial cell proliferation, stratified epithelium, microscopic papillary projections, cellular pleomorphism, nuclear atypia, and mitotic activity. In addition, there can be no stromal invasion, which is what differentiates them from invasive carcinomas.
However, in 10% of BOT, there are areas of microinvasion, with cells with the same features as BOT, defined by foci of < 5 mm or that do not invade the stroma > 10 mm2. The stromal microinvasion is a controversial independent prognostic factor since it appears more frequently in serous BOT, and is associated with a higher frequency of micropapillary pattern and the appearance of peritoneal implants. It is considered a predictor of recurrence in invasive form.
The peritoneal extension of BOT, called implants, are characterised as non-invasive (85%) when the epithelial proliferation affects only the peritoneal surface; while with invasive implants, there occurs in addition an extension to the underlying tissue, such as the omentum or intestinal wall.
Once the BOTs are completely removed surgically they may recur, and may be of the borderline type (the majority), in which case survival is not affected, or of the invasive carcinoma type, in which case, the prognosis of these patients may be drastically affected.
Management and prognostic factors
The surgical treatment of BOT depends on the age of the patient, their reproductive wishes, the stage at diagnosis, and the presence or absence of invasive implants.
The FIGO stage classification is considered to be the greatest prognostic factor for recurrence and survival of BOT, as it is in invasive carcinomas, but in contrast to these, the overall survival rate is greater. Published studies concluded that there was a 97–99% survival rate at five years when diagnosed at stage I, which decreased to 70–95% at ten years due to late recurrences; and to 65–87% in stages II and III at five years.
Surgical staging is based on operative findings, and consists in carrying out all procedures in the standardised clinical guides explained below, either in a first surgery or a second, if required, although there is a great deal of controversy around a second because it does not appear to affect patient survival. A surgery will be considered ‘incomplete’ in cases where not all procedures were carried out, except in cases where preserving fertility was a concern, in which case, all procedures except hysterectomy and unilateral adnexectomy were performed. +Table 1. Factors for bad BOT prognosis.FIGO stages (II-III-IV) Mucinous BOT Invasive implants Papillary pattern Incomplete surgery Microinvasion Conservative surgery Intracystic carcinoma Age >40 years Extraovarian relapse Non-optimal staging in patients with BOT has a poor prognosis (Table 1), because without a deep peritoneal exploration, there could be invasive peritoneal implants. The importance of correct surgical staging lies in the need for a change in surgical treatment and postoperative adjuvant treatment if any added pathology is present. Theoretically, long-term survival would be diminished in patients with non-optimal staging with invasive implants, although the data do not seem to be statistically significant in the literature, probably due to the good overall prognosis of BOT and the low number of cases of each series. In addition, non-optimal staging is considered a predictor of relapse, since women with incomplete surgery present a higher relapse rate, as high as double.
In spite of the fact that only 15% of unilateral tumours are associated with peritoneal extension, compared with 56% for bilateral, and with both radical and conservative surgeries as objectives, it would seem the most sensible course would be to perform complete surgical staging. However, this continues to be a topic for discussion. This surgery would be performed as an initial surgery upon getting an intraoperative diagnosis of BOT, or in a second surgery if the diagnosis was delayed after a chance intraoperative discovery, for example. It should be borne in mind that intraoperative analysis using fresh frozen samples tends to under diagnose BOT as benign tumours in 25–30% of cases, and carcinomas as BOT in 20–30%.
Radical surgery In postmenopausal women, and in those who have fulfilled their reproductive wishes, the following standardised procedures will be carried out: a thorough exploration of the abdominal cavity, bilateral salpingo-oophorectomy, total hysterectomy, inframesocolic omentectomy, peritoneal lavage to obtain samples for cytology, resection of macroscopically suspicious lesions, and multiple peritoneal biopsies (including omentum, intestinal serosa, mesentery, pelvic, and abdominal peritoneum), although this practice is in disuse due to its low sensitivity and the apparent lack of utility of randomised biopsies where no suspicious lesions are present.
In addition, in cases of mucinous BOT, appendectomies are performed to exclude ovarian metastasis whose origin is a primary carcinoma of the appendix.
Table 1. Factors for bad BOT prognosis.
Pelvic and paraaortic lymphadenectomy is not considered necessary since the involvement of lymph nodes does not decrease survival, and resection of these does not increase it. Lymphatic involvement, despite having no prognostic value in BOT, is an area associated with a recurrence or a progression to carcinoma, but this is exceptional and therefore justified by the morbidity associated with systematic lymphadenectomy in staging.