TDI may refer to:

Science and technology Tolerable daily intake, in toxicology Toluene diisocyanate, an organic chemical Time delay and integration, timing synchronization in an image sensor Tissue Doppler imaging, a medical ultrasound technology Tabbed document interface, a type of graphical user interface Total dual integrality, a property of matrices in mathematical optimization Transport Driver Interface, used by NT series Windows to abstract level 7 APIs into a common protocol for the Transport Protocol layer Trophic Diatom Index, water quality and ecological status; see Sattal TDI (engine) (turbocharged direct injection), a diesel engine design used in cars and light vans made by Volkswagen Group

Organizations Technical Diving International, a technical diving organization Telecommunications for the Deaf, Inc., a nonprofit organization promoting telecommunications devices for the deaf Texas Department of Insurance The Dartmouth Institute for Health Policy and Clinical Practice, a subsidiary of Dartmouth College Transportation Displays, Inc., a unit of Outfront Media Technical group of Independents (1999-2001) Technical group of Independents (1979-1984)

Entertainment Total Drama Island, an animated reality series Total Drama Island (2023), the 2023 reboot with the same name. Tangerine Dream Independent, the record label belonging to Edgar Froese