Alessandrini is an Italian surname. Notable people with the surname include:
Anthony Alessandrini (1921–1988), American jazz pianist Antonio Alessandrini (1786–1861), Italian zoologist Cristian Alessandrini (born 1985), Argentine footballer Elia Alessandrini (1997–2022), Swiss footballer Gerard Alessandrini (born 1953), American playwright Giancarlo Alessandrini (born 1950), Italian comic artist Giulio Alessandrini (1506–1590), Italian Renaissance physician Giulio Alessandrini (parasitologist) (1866–1954), Italian parasitologist Goffredo Alessandrini (1904–1978), Italian script writer and film director Lorenza Alessandrini (born 1990), Italian ice dancer Marco Alessandrini (born 1970), Italian politician Marjorie Alessandrini (1946–2014), French journalist, Patricia Alessandrini (born 1970), American composer and musician Renato Alessandrini (1890–1928), Italian explorer Rinaldo Alessandrini (born 1960), Italian musician Romain Alessandrini (born 1989), French footballer Valeria Alessandrini (born 1975), Italian politician
See also Parco Emilio Alessandrini, memorial park in Milan, Italy