Francis Willis may refer to:
Francis Willis (academic) (died 1597), English academic administrator at the University of Oxford and Dean of Worcester Francis Willis (physician) (1718–1807), British physician and clergyman, known for his treatment of George III Francis Willis (politician) (1745–1829), United States representative from Georgia
See also Frank Willis (disambiguation) Frances E. Willis (1899–1983), third woman to enter the U.S. Foreign Service