Middletown Historic District may refer to:
United States (by state then city) Middletown Upper Houses Historic District, Cromwell, Connecticut, listed on the National Register of Historic Places (NRHP) in Middlesex County, Connecticut Middletown South Green Historic District, Middletown, Connecticut, listed on the NRHP in Middlesex County, Connecticut Middletown Historic District (Middletown, Delaware), listed on the NRHP in New Castle County, Delaware Middletown Historic District (Alton, Illinois), listed on the NRHP in Madison County, Illinois Middletown Historic District (Middletown, Maryland), listed on the NRHP in Frederick County, Maryland Middletown Village Historic District, Middletown, New Jersey, listed on the NRHP in Monmouth County, New Jersey West Middletown Historic District, West Middletown Borough, Pennsylvania, listed on the NRHP in Washington County, Pennsylvania Middletown Rural Historic District, Grafton, Vermont, listed on the NRHP in Windham County, Vermont Middletown Springs Historic District, Middletown Springs, Vermont, listed on the NRHP in Rutland County, Vermont Middletown Historic District (Middletown, Virginia), listed on the NRHP in Frederick County, Virginia