Chodzko or Chodźko is a surname. Notable people with the surname include:
Adam Chodzko (born 1965), British multimedia artist Aleksander Chodźko (1804–1891), Polish poet, Slavist, and Iranologist Leonard Chodźko (1800–1871), Polish historian, geographer, cartographer, and publisher Lysette Anne Chodzko (born 26 September 1963), known professionally as Lysette Anthony, English actress and model Witold Chodźko (1875–1954), Polish social activist, public health pioneer, neurologist and psychiatrist