The Tetramelaceae are a family of plants in the order Cucurbitales, containing two genera of mostly Asian, large trees, Octomeles and Tetrameles, each with a single species. These genera were formerly placed in the Datiscaceae,van Steenis CGGJ (1953) Datiscaceae. Fl. Males., Ser. I, Spermat. 4: 382–387. but genetic studies confirmed that they do not form a natural clade with the other members of that family.
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