McCombie is a surname. Notable people with the surname include:
Andy McCombie (1876–1952), Scottish international footballer Karen McCombie (born 1963), author of children and young adult novels William McCombie (1805–1880), Scottish agriculturist famed for a herd of black-polled cattle
See also Barton–McCombie deoxygenation, organic reaction replacing a hydroxy group with hydrogen to give an alkyl group