Hillsboro Historic District may refer to:
in the United States (by state then city) Hillsborough Historic District, Hillsborough, North Carolina, listed on the National Register of Historic Places (NRHP) Hillsboro Historic Business District, Hillsboro, Ohio, listed on the NRHP in Highland County, Ohio Hillsboro-West End Historic District, Nashville Tennessee, listed on the NRHP in Davidson County, Tennessee Hillsboro Residential Historic District, Hillsboro Texas, listed on the NRHP in Hill County, Texas Hillsboro Historic District (Hillsboro, Virginia), NRHP-listed Hillsborough (Walkerton, Virginia), listed on the NRHP in King and Queen County, Virginia