House at 115 South Main Street is a historic home located at Canastota in Madison County, New York. It was built in the mid-1850s and remodeled in the 1880s in the Queen Anne and Eastlake styles. It is a modest -story structure surmounted by a multi-gabled roof, which is pierced by a -story tower. ()
It was added to the National Register of Historic Places in 1986.
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