Sisler or Šisler may refer to:
Cathy Sisler, American artist Dave Sisler (1931–2011), former pitcher who played in Major League Baseball 1956–1962 Dick Sisler (1920–1998), American player, coach and manager in Major League Baseball George Sisler (disambiguation), several people with this name, including: George Sisler (1893–1973), American Major League Baseball first baseman and member of the National Baseball Hall of Fame Jan Šisler (born 1988), Czech footballer Jiří Šisler (born 1984), Czech footballer
See also Sisler High School, the largest high school in the province of Manitoba with over 1700 students USNS Sisler (T-AKR-311), one of Military Sealift Command's nineteen Large, Medium-Speed Roll-on/Roll-off Ships