Fowlkes is a surname. Notable people with the surname include:
Alan Fowlkes (born 1958), American retired professional baseball player Charles Fowlkes (1916–1980), American baritone saxophonist Curtis Fowlkes (1950–2023), American jazz trombonist Eddie Fowlkes (born 1962), American techno DJ Herman Fowlkes Jr. (1919–1993), American jazz musician and educator Lauren Fowlkes (born 1988), American soccer player Tremaine Fowlkes (born 1976), American professional basketball player