The 2010 NRL season consisted of 26 weekly regular season rounds, starting on 12 March and ending on 5 September, followed by four weeks of play-offs culminating in the grand final on 3 October.

Regular season Round 1 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd Brisbane Broncos30 – 24 North Queensland Cowboys12 March 2010, 7:35 pmSuncorp StadiumJared MaxwellGerard Sutton48,516 Parramatta Eels12 – 18 St. George Illawarra Dragons12 March 2010, 7:35 pmParramatta StadiumTony ArcherGavin Badger18,293 Canterbury-Bankstown Bulldogs16 – 20 Newcastle Knights13 March 2010, 5:30 pmANZ StadiumJason RobinsonBernard Sutton18,110 Penrith Panthers34 – 16 Canberra Raiders13 March 2010, 7:30 pmCUA StadiumSteve LyonsAlan Shortall11,133 Cronulla-Sutherland Sharks10 – 14 Melbourne Storm13 March 2010, 7:30 pmToyota StadiumBen CumminsBrett Suttor11,820 Gold Coast Titans24 – 18 New Zealand Warriors14 March 2010, 1:00 pmSkilled ParkMatt CecchinChris James16,112 South Sydney Rabbitohs10 – 36 Sydney Roosters14 March 2010, 3:00 pmANZ StadiumTony De Las HerasAshley Klein23,149 Wests Tigers26 – 22 Manly Warringah Sea Eagles 15 March 2010, 7:00 pmSydney Football StadiumGavin BadgerJared Maxwell18,421 For the first time since 2006, the Penrith Panthers opened their season with a victory.

Round 2 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd St. George-Illawarra Dragons26 – 6 Canterbury-Bankstown Bulldogs19 March 2010, 7:35 pmWIN StadiumTony Archer Matt Cecchin16,177 South Sydney Rabbitohs18 – 19 Gold Coast Titans19 March 2010, 8:35 pmANZ StadiumTony De Las Heras Ashley Klein10,943 New Zealand Warriors30 – 16 Cronulla-Sutherland Sharks20 March 2010, 7:30 pmMt Smart StadiumJason Robinson Bernard Sutton15,314 Newcastle Knights14 – 20 Melbourne Storm 20 March 2010, 7:30 pmEnergyAustralia StadiumSteve Lyons Alan Shortall16,242 North Queensland Cowboys28 – 20 Penrith Panthers20 March 2010, 8:30 pmDairy Farmers StadiumBen Cummins Chris James13,335 Parramatta Eels 24 – 20 Manly Warringah Sea Eagles21 March 2010, 2:00 pmParramatta StadiumShayne Hayne Brett Suttor15,602 Sydney Roosters44 – 32 Wests Tigers21 March 2010, 3:00 pmSydney Football StadiumJarred Maxwell Gerard Sutton19,021 Canberra Raiders22 – 14 Brisbane Broncos 22 March 2010, 7:00 pmCanberra StadiumGavin Badger Phil Haines14,200 Greg Inglis of the Melbourne Storm played his 100th club game.

Round 3 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd Wests Tigers23 – 12 Parramatta Eels26 March 2010, 7:35 pmSydney Football StadiumTony Archer Matt Cecchin21,318 St. George Illawarra Dragons33 – 8 North Queensland Cowboys26 March 2010, 8:35 pmWIN StadiumJared Maxwell Gerard Sutton13,267 Penrith Panthers10 – 16 Melbourne Storm27 March 2010, 5:30 pmCUA StadiumGavin Badger Phil Haines11,024 Manly Warringah Sea Eagles36 – 12 Newcastle Knights27 March 2010, 7:30 pmBluetongue StadiumTony De Las Heras Ashley Klein12,138 Gold Coast Titans24 – 4 Canberra Raiders27 March 2010, 7:30 pmSkilled ParkBen Cummins Chris James11,521 Brisbane Broncos16 – 48 New Zealand Warriors28 March 2010, 1:00 pmSuncorp StadiumSteve Lyons Alan Shortall32,338 Canterbury-Bankstown Bulldogs60 – 14 Sydney Roosters28 March 2010, 3:00 pmANZ StadiumJason Robinson Bernard Sutton19,738 Cronulla-Sutherland Sharks8 – 30 South Sydney Rabbitohs29 March 2010, 7:30 pmToyota StadiumShayne Hayne Brett Suttor10,741 The Cronulla-Sutherland Sharks lost their 13th straight match, squalling the competition record for a losing streak since the NRL's inception in 1998. The St. George Illawarra Dragons' victory meant for the first time they won the first three matches of the season. The Brisbane Broncos conceded the highest number of points ever in a home game. The Roosters' 60–14 defeat was the highest number of points conceded for the team since the NRL inception in 1998. Fuifui Moimoi of the Parramatta Eels played his 100th career club game.

Round 4 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd Melbourne Storm17 – 4 St. George Illawarra Dragons2 April 2010, 2:10pmEtihad StadiumJared MaxwellGerard Sutton25,480 Sydney Roosters25 – 6 Brisbane Broncos2 April 2010, 8:35pmSydney Football StadiumTony ArcherMatt Cecchin17,106 Cronulla-Sutherland Sharks11 – 0 Parramatta Eels3 April 2010, 5:30pmToyota StadiumTony De Las HerasAshley Klein13,213 North Queensland Cowboys32 – 18 Gold Coast Titans3 April 2010, 6:30pmDairy Farmers StadiumSteve LyonsAlan Shortall15,551 Canberra Raiders22 – 35 Wests Tigers4 April 2010, 3:00pmCanberra StadiumShayne HayneBrett Suttor17,112 New Zealand Warriors6 – 14 Manly Warringah Sea Eagles4 April 2010, 4:00pmMt Smart StadiumBen CumminsChris James19,230 Newcastle Knights30 – 34 Penrith Panthers5 April 2010, 4:00pmEnergyAustralia StadiumJason RobinsonBernard Sutton15,894 South Sydney Rabbitohs38 – 16 Canterbury-Bankstown Bulldogs5 April 2010, 7:00pmANZ StadiumGavin BadgerPhil Haines30,120 Nathan Cayless of the Parramatta Eels became the first player to record 200 games as club captain. The crowd of 25,480 at Etihad Stadium recorded Melbourne's highest ever regular season home crowd figure. The Sydney Roosters defeated the Brisbane Broncos at the SFS on Good Friday for the first time since 2003. Tim Sheens of the Wests Tigers recorded his 300th victory as a coach. The Cronulla-Sutherland Sharks ended their longest losing streak (13) this round. The North Queensland Cowboys defeated the Gold Coast Titans at home for the first time.

Round 5 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd St. George Illawarra Dragons34 – 16 Brisbane Broncos9 April 2010, 7:35 pmWIN StadiumMatt CecchinAshley Klein15,374 Gold Coast Titans20 – 16 Melbourne Storm9 April 2010, 7:35 pmSkilled ParkBen CumminsJared Maxwell20,083 South Sydney Rabbitohs28 – 10 Newcastle Knights10 April 2010, 5:30 pmBluetongue StadiumPhil HainesSteve Lyons16,098 Canterbury-Bankstown Bulldogs24 – 30 New Zealand Warriors 10 April 2010, 7:30 pmANZ StadiumTony De Las HerasJason Robinson17,095 North Queensland Cowboys16 – 23 Wests Tigers10 April 2010, 7:30 pmDairy Farmers StadiumGavin BadgerBrett Suttor16,273 Manly Warringah Sea Eagles40 – 12 Cronulla-Sutherland Sharks11 April 2010, 2:00 pmBrookvale OvalTony ArcherAlan Shortall16,055 Penrith Panthers28 – 6 Sydney Roosters11 April 2010, 3:00 pmCUA StadiumJared MaxwellBernard Sutton14,023 Parramatta Eels14 – 24 Canberra Raiders12 April 2010, 7:00 pmParramatta StadiumBen CumminsGerard Sutton15,122

Round 6 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd Gold Coast Titans6 – 19 St. George Illawarra Dragons16 April 2010, 7:35 pmSkilled ParkTony ArcherJason Robinson21,336 Wests Tigers4 – 24 Canterbury-Bankstown Bulldogs16 April 2010, 7:35 pmSydney Football StadiumJared MaxwellBernard Sutton 19,491 Newcastle Knights36 – 18 North Queensland Cowboys17 April 2010, 5:30pmEnergyAustralia StadiumChris JamesAshley Klein14,205 Sydney Roosters36 – 6 Canberra Raiders17 April 2010, 7:30pmSydney Football StadiumMatt CecchinSteve Lyons9,308 New Zealand Warriors12 – 40 Penrith Panthers18 April 2010, 2:00pmMt Smart StadiumGavin BadgerBrett Suttor 14,620 Brisbane Broncos44 – 16 Cronulla-Sutherland Sharks18 April 2010, 2:00pmSuncorp StadiumTony De Las HerasJason Robinson 25,688 Parramatta Eels22 – 8 South Sydney Rabbitohs18 April 2010, 3:00pmANZ StadiumBen CumminsGerard Sutton25,152 Melbourne Storm16 – 18 Manly Warringah Sea Eagles19 April 2010, 7:00pmEtihad StadiumTony ArcherAlan Shortall14,171 Nathan Hindmarsh became the Parramatta Eels' most capped player, overtaking Brett Kenny by playing his 266th game. Glenn Stewart of the Manly Warringah Sea Eagles played his 100th club game. Luke Priddis played his 300th career match with the St. George Illawarra Dragons. The Melbourne Storm fell to its first defeat at Etihad Stadium since 2001. The Canberra Raiders' loss to the Roosters was their 12th successive defeat at the Sydney Football Stadium against that opposition, a record that stretches back to 1995.

Round 7 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd Canterbury-Bankstown Bulldogs36 – 18 Brisbane Broncos23 April 2010, 7:35pmANZ StadiumGavin BadgerJared Maxwell17,014 North Queensland Cowboys18 – 24 Parramatta Eels23 April 2010, 7:35pmDairy Farmers StadiumTony De Las HerasJason Robinson11,335 Penrith Panthers26 – 18 Wests Tigers24 April 2010, 5:30pmCUA StadiumShayne HayneChris James19,220 Cronulla-Sutherland Sharks26 – 6 Newcastle Knights24 April 2010, 7:30pmToyota StadiumPhil HainesAshley Klein10,662 Canberra Raiders24 – 26 South Sydney Rabbitohs25 April 2010, 2:00pmCanberra StadiumMatt CecchinSteve Lyons13,145 St. George Illawarra Dragons 28 – 6 Sydney Roosters25 April 2010, 4:00pmSydney Football StadiumTony ArcherAlan Shortall36,212 Melbourne Storm40 – 6 New Zealand Warriors25 April 2010, 6:00pmEtihad StadiumGavin BadgerBrett Suttor23,906 Manly Warringah Sea Eagles22 – 24 Gold Coast Titans26 April 2010, 7:00pmBrookvale OvalJared MaxwellBernard Sutton15,195 From round 7, the Melbourne Storm will not be allowed to earn any further competition points for the rest of the 2010 season due to salary cap breaches. The Parramatta Eels won its first match at Dairy Farmers Stadium since 2000, whilst the South Sydney Rabbitohs won its first match in Canberra Stadium since 2005.

Round 8 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd Parramatta Eels26 – 10 Canterbury-Bankstown Bulldogs30 April 2010, 7:35pmANZ StadiumTony ArcherShayne Hayne31,911 Brisbane Broncos22 – 30 Newcastle Knights30 April 2010, 7:35pmSuncorp StadiumMatt CecchinSteve Lyons25,178 New Zealand Warriors16 – 23 Canberra Raiders1 May 2010, 5:00pmMt Smart StadiumBen CumminsAdam Devcich11,499 Gold Coast Titans38 – 24 Penrith Panthers1 May 2010, 5:30pmSkilled ParkJared MaxwellBernard Sutton15,430 North Queensland Cowboys6 – 34 Melbourne Storm1 May 2010, 7:30pmDairy Farmers StadiumGavin BadgerBernard Sutton19,853 St. George Illawarra Dragons38 – 0 Cronulla-Sutherland Sharks1 May 2010, 7:30pmWIN StadiumTony De Las HerasJason Robinson15,779 Wests Tigers8 – 12 Sydney Roosters2 May 2010, 2:00pmCampbelltown StadiumAshley KleinMatt Cecchin19,901 South Sydney Rabbitohs22 – 30 Manly Warringah Sea Eagles2 May 2010, 3:00pmANZ StadiumTony ArcherAlan Shortall15,459 This round Wests Tigers coach Tim Sheens became the first coach ever to reach 600 games.

Round 9 HomeScoreAwayMatch InformationDate and Time (Local)VenueRefereesCrowd Manly Warringah Sea Eagles 24 – 6 St. George Illawarra Dragons8 May 2010, 7:30pmBrookvale OvalGavin BadgerShayne Hayne16,745 Newcastle Knights 36 – 38 Gold Coast Titans9 May 2010, 2:00pmEnergyAustralia StadiumBen CumminsAlan Shortall13,384 Melbourne Storm 14 – 36 Brisbane Broncos9 May 2010, 3:00pmAAMI ParkTony ArcherSteve Lyons20,032 Sydney Roosters14 – 32 North Queensland Cowboys10 May 2010, 7:00pmSydney Football StadiumAshley KleinJason Robinson6,478BYE Round for: 8 teams - Canterbury-Bankstown Bulldogs, Canberra Raiders, Parramatta Eels, Penrith Panthers, Cronulla-Sutherland Sharks, South Sydney Rabbitohs, New Zealand Warriors & Wests Tigers . No club games were played on Friday night due to the 2010 ANZAC Test and City vs Country Origin representative matches being played on that day. The Gold Coast Titans won their first ever game at EnergyAustralia Stadium. The Brisbane Broncos became the first team to post a NRL victory at AAMI Park by defeating home team the Melbourne Storm. Their win was also the first in any Storm home ground (Olympic Park Stadium and Docklands Stadium) since 2003.

Round 10 - Heritage Round