4C-T-2

4C-T-2, also known as 2,5-dimethoxy-4-ethylthio-α-ethylphenethylamine, is a synthetic drug of the phenethylamine, phenylisobutylamine, and 4C families. It is the α-ethylated analogue of 2C-T-2.

Pharmacology Pharmacodynamics + Target Affinity (Ki, nM) 5-HT1A 5,339 5-HT1B >10,000 5-HT1D >10,000 5-HT1E 9,879 5-HT1F 5-HT2A 274 (Ki)13.1–53 ()78% () 5-HT2B 58.1 (Ki)630 () () 5-HT2C 469 (Ki)7.3–13.2 ()86–121% () 5-HT3 >10,000 5-HT4 5-HT5A 1,587 5-HT6 >10,000 5-HT7 3,829 α1A, α1B >10,000 α1D α2A–α2C >10,000 β1 >10,000 β2 124.9 β3 D1, D2 >10,000 D3 1,273 D4, D5 >10,000 H1–H4 >10,000 M1–M5 >10,000 I1 946.5 σ1 514.6 σ2 >10,000 >10,000 (Ki) >10,000 (Ki) >10,000 (Ki) 11,800 () >100,000 () Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs:

4C-T-2 acts as a serotonin 5-HT2 receptor agonist, including of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors.

History 4C-T-2 was first described in the scientific literature by at least 2005. It was more fully characterized in 2010 and then in 2023.

4C-T-2

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