Charles Sprague may refer to:
Charles Sprague (poet) (1791–1875), American poet Charles James Sprague (1823–1903), American botanist Charles Sprague Smith (1853–1910), activist and founder of the People's Institute during the Progressive era Charles A. Sprague (1887–1969), Governor of Oregon, 1939–1943 Charles Ezra Sprague (1842–1912), American accountant Charles F. Sprague (1857–1902), U.S. Representative from Massachusetts Charlie Sprague (1864–1912), American baseball player