Mesotes is a genus of snakes of the family Colubridae.

Geographic range All species in the genus Mesotes are endemic to South America.

Species The following 2 species are recognized as being valid. Mesotes rutilus Prado, 1942 - Prado's coastal house snake Mesotes strigatus (Günther, 1858) -coastal house snake

Nota bene: A binomial authority in parentheses indicates that the species was originally described in a genus other than Mesotes.

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