Guastavino is a surname. Notable people with the surname include:
Rafael Guastavino (1842–1908), Spanish architect and builder Rafael Guastavino III (1872–1950), Spanish architect Jean-Marie Guastavino (1886-1960), French politician Carlos Guastavino (1912-2000), Argentine composer Pedro Guastavino (born 1954), Argentine politician Diego Guastavino (born 1984), Uruguayan football player Vera Guastavino (born 1957), Belgian Physician
See also Guastavino tile, patented by Rafael Guastavino in 1885