Puerto Rico currently has the fourth-most active players in Major League Baseball (MLB) among Latin American jurisdictions, behind the Dominican Republic, Venezuela and Cuba. More than four hundred players from the archipelago have played in the major leagues since . This includes players who were born in either one of the archipelago's islands and those of Puerto Rican heritage. Only those players who have worked in the major leagues are listed, not those active in the minor leagues, nor negro independent leagues.

For years, it was considered that the first player from Puerto Rico to play in the major leagues was Hiram Bithorn in 1942. But this changed in December 2020, when seven Negro baseball leagues between 1920 and 1948 were recognized as "major leagues." Thus, the first Puerto Rican to play baseball on the major leagues was Jose "Gacho" Torres, who debuted in 1926.

After the baseball color line was abandoned following Jackie Robinson's debut in the National League of MLB, more players from the island signed contracts. This led to an improvement in their performance, and some of them were selected to participate in the Major League Baseball All-Star Game. Including their names in the Major League Baseball draft is a requisite for first-year players born in Puerto Rico, because the league recognizes the island as a jurisdiction within the United States. Following the implementation of this measure, Puerto Rico's government requested exclusion from the draft and help to develop players, in order to reduce the impact of the change in the format of talent development.

Historical performance and regulations Baseball was introduced to Puerto Rico by immigrants during the nineteenth century. The first sanctioned baseball game in the island was played on January 9, 1898, in Santurce, Puerto Rico, where two teams composed of Puerto Rican, American and Cuban players participated. After this game, baseball became a widespread sport and professional and amateur leagues were organized. During this time period, the Puerto Rico national teams experienced success on international competition and Afro-Puerto Rican players began to participate in the Negro leagues.

Hiram Bithorn debuted as a pitcher with the Chicago Cubs on April 15, 1942, but before him, there were about 10 other players who worked on the negro leagues, now considered as major leagues. About 17 other Puerto Rican players in the negro leagues were active right before the introduction of African American players in Major League Baseball, and thus, there were more chances to players born in the island. Subsequently, Afro-Puerto Rican players such as Orlando Cepeda and Victor Pellot Power began having solid performances in the league, and were selected to participate in the Major League Baseball All-Star Game. In , Roberto Clemente became the first player from Puerto Rico and first Latin American to be elected as a member of the National Baseball Hall of Fame and Museum. Since then Puerto Rico has kept a stable number of players in the league. During this timeframe, several players have been selected to participate in the All-Star Game or won awards for their performance, while others imposed records within the league. These include Javy López, who holds the record for most home runs hit by a catcher in a single season. Both Iván Rodríguez and Roberto Alomar hold the record for most Gold Glove Awards in their positions. Recipients of the Most Valuable Player Award include Orlando Cepeda, Juan González and Iván Rodríguez. Roberto Clemente and Mike Lowell also won the World Series MVP Award in their respective divisions. Carlos Delgado is the only Latin to hit 4 homers in a game.

Originally, players who were either born or naturalized in Puerto Rico were able to sign with MLB teams as free agents, usually receiving minor-league contracts prior to their debut in the league. In , Major League Baseball decided to include the island in the list of jurisdictions within the United States, which made mandatory that first-year players include their name in the Major League Baseball Draft in order to receive a contract. This was based on an initiative that was supposed to create a national and international drafting system. The change reduced the number of players that were able to participate in the league, by limiting the number of them selected by the teams; this led to the island's Secretary of Recreation and Sports, to formally ask to Major League's involvement in developing specialized schools to produce more players and other measures to reduce the impact of the draft's implementation. The original proposal included Puerto Rico's exclusion of the draft for a period of ten years, but this was not approved by the league.

Puerto Rico was one of sixteen teams to participate in the inaugural edition of the World Baseball Classic. The tournament was created by Major League Baseball, the Major League Baseball Players Association, and other professional baseball leagues and their players associations around the world, including the Puerto Rican Professional Baseball League. The first event was organized in 2006, and was sanctioned by the International Baseball Federation. Puerto Rico won the silver medal on both 2013 and 2017 classics. The Hiram Bithorn Stadium in San Juan, Puerto Rico hosted 22 Montreal Expos home games in , after the league decided to relocate the team to San Juan as part of an experiment to "globalize" baseball. During the series there was an average attendance of 14,222.

List of players This list includes players born in Puerto Rico and players born outside of Puerto Rico to a Puerto Rican parent.

A–E

Name Debut team Years active ReferenceJuan AgostoChicago White Sox 1981–1993Luis AguayoPhiladelphia Phillies 1980–1989Jonathan AlbaladejoWashington Nationals 2007–2012José AlberroTexas Rangers 1995–1997Luis AlcarazLos Angeles Dodgers 1967–1970Luis AliceaSt. Louis Cardinals 1988–2002Roberto AlomarSan Diego Padres 1988–2004Sandy Alomar Jr.San Diego Padres 1988–2007Sandy Alomar Sr.Milwaukee Braves 1964–1978Luis AlvaradoBoston Red Sox 1968–1977Orlando ÁlvarezLos Angeles Dodgers 1973–1976Robert AndinoFlorida Marlins 2005–2013Luis AquinoToronto Blue Jays 1986–1995Jake ArrietaBaltimore Orioles 2010–2022Christian ArroyoSan Francisco Giants 2017–2023Edwin ArroyoCincinnati Reds 2026Luis ArroyoSt. Louis Cardinals 1955–1963Rudy ArroyoSt.Louis Cardinals 1971Luis AtilanoWashington Nationals 2010Mike AvilésKansas City Royals 2011–2017Ramón AvilésBoston Red Sox 1977–1981Benny AyalaNew York Mets 1974–1985Carlos BaergaCleveland Indians 1990–2005Javier BáezChicago Cubs 2014–presentKevin BaezNew York Mets 1990–1993Aaron BatesBoston Red Sox 2009Carlos BeltránKansas City Royals 1998–2017Juan BeníquezBoston Red Sox 1971–1987Yamil BenítezMontreal Expos 1995–1998Jonathan BermúdezMiami Marlins 2024Tony BernazardMontreal Expos 1979–1991Carlos BernierPittsburgh Pirates 1953José BerríosMinnesota Twins 2016–presentHiram BithornChicago Cubs 1942–1947Hiram BocachicaLos Angeles Dodgers 2000–2007Ricky BonesSan Diego Padres 1991–2001Bobby BonillaChicago White Sox 1986–2001Juan BonillaSan Diego Padres 1981–1987Hiram BurgosMilwaukee Brewers 2013Raymond BurgosSan Francisco Giants 2024Fernando CabreraCleveland Indians 2004–2010Luis CabreraIndianapolis Clowns 1948Jac CaglianoneKansas City Royals 2025Ivan CalderónSeattle Mariners 1984–1993Kiko CaleroSt. Louis Cardinals 2003–2009Luis CampusanoSan Diego Padres 2020–2021Robinson CancelMilwaukee Brewers 1999–2011John CandelariaPittsburgh Pirates 1975–1993John CangelosiChicago White Sox 1985–1999Víctor CaratiniChicago Cubs 2017–presentJavier CardonaDetroit Tigers 2000–2002Rafael CarmonaSeattle Mariners 1995–1999Raúl CasanovaDetroit Tigers 1996–2009Ramón CastroFlorida Marlins 1999–2011Willi CastroDetroit Tigers 2019–presentXavier CedeñoWashington Nationals 2011–2019Juan CentenoNew York Mets 2013–2019Orlando CepedaSan Francisco Giants 1958–1974Leonardo ChapmanBaltimore Elite Giants 1944Alex CintrónArizona Diamondbacks 2001–2010Alex ClaudioTexas Rangers 2014–2021Edgard ClementeColorado Rockies 1998–2000Roberto ClementePittsburgh Pirates 1955–1972Jaime CocanowerMilwaukee Brewers 1983–1986Pancho CoimbreNew York Cubans 1940–1944Willie CollazoNew York Mets 2007Christian ColónKansas City Royals 2014–2020Joe ColónCleveland Indians 2016Monchile ConcepciónPhila. Bacharach Giants 1934Onix ConcepciónKansas City Royals 1980–1987Ramón CondeChicago White Sox 1962Alex CoraLos Angeles Dodgers 1998–2011Joey CoraSan Diego Padres 1987–1998Wil CorderoMontreal Expos 1992–2005Carlos CorporánHouston Astros 2009–2015Carlos CorreaHouston Astros 2015–presentEdwin CorreaChicago White Sox 1985–1987Carlos CortesOakland Athletics 2025Fernando CortezTampa Bay Devil Rays 2005–2007Henry CottoChicago Cubs 1984–1993César CrespoSan Diego Padres 2001–2004Felipe CrespoToronto Blue Jays 1996–2001Fernando CruzCincinnati Reds 2022-presentHéctor CruzSt. Louis Cardinals 1973–1982Henry CruzLos Angeles Dodgers 1975–1978Julio CruzSeattle Mariners 1977–1986Iván CruzNew York Yankees 1997–2002José CruzSt. Louis Cardinals 1970–1988José Cruz Jr.Seattle Mariners 1997–2008Cirilo "Tommy" CruzSt. Louis Cardinals 1973–1977Trei CruzDetroit Tigers 2026Noel CuevasColorado Rockies 2018–2019David DeJesusKansas City Royals 2003–2015José DeJesúsKansas City Royals 1988–1994Iván DeJesúsLos Angeles Dodgers 1974–1988Iván DeJesús Jr.Los Angeles Dodgers 2011–2016José De La TorreBoston Red Sox 2013Adrian Del CastilloArizona Diamondbacks 2024-presentJosé De LeónLos Angeles Dodgers 2016–2021Luis DeLeónSt. Louis Cardinals 1981–1989Carlos DelgadoToronto Blue Jays 1993–2009Felle DelgadoNew York Cubans 1941Puchy DelgadoSeattle Mariners 1977Joe DeSaSt. Louis Cardinals 1980Alex DíazMilwaukee Brewers 1992–1999Alexis DíazCincinnati Reds 2022-presentCarlos DiazAtlanta Braves 1982–1986Edgar DíazMilwaukee Brewers 1986–1990Edwin DíazArizona Diamondbacks 1998–1999Edwin DíazNew York Mets 2016–presentIsan DíazMiami Marlins 2019–2020Jonathan DiazBoston Red Sox 2013–2015Mario DíazSeattle Mariners 1987–1995Mike DíazChicago Cubs 1983–1988Angel EchevarríaColorado Rockies 1996–2002Christian Encarnacion-StrandCincinnati Reds 2023-presentNino EscaleraCincinnati Redlegs 1954José EspadaSan Diego Padres 2023, 2025

F–L