Margolies (also Margulies or Margolyes) is a surname that, like its variants shown below, is derived from the Ashkenazi Hebrew pronunciation of the Hebrew word (), meaning 'pearls'. Notable people with the surname include:

Marjorie Margolies-Mezvinsky (born 1942), American politician from Philadelphia. Moses S. Margolies (1851–1936), Russian-born American Orthodox rabbi. Rob Margolies (born 1983), American film director and screenwriter Reuvein Margolies (1889–1971), Israeli author and Talmudic scholar.

See also