James Preston may refer to: James H. Preston (1860–1938), mayor of Baltimore James Moore Preston (1873–1962), American painter and illustrator James Patton Preston (1774–1843), U.S. political figure James Rhea Preston (1853–1922), American educator in Mississippi James Preston (cricketer) (1792–1842), English cricketer James B. Preston (politician) (died 1902), American politician James B. Preston (1926–2004), American neurophysiologist James Preston (runner) (born 1997), track and field athlete from New Zealand
See also Jimmy Preston (1913–1984), R&B bandleader