Luperón may refer to:
People Gregorio Luperón (1839–1897), president of the Dominican Republic 1879–1880 Ramón Luperón (born 1946), Cuban rower
Other uses Luperón, Dominican Republic, a town on the northern coast of the Dominican Republic Gregorio Luperón International Airport, an airport in the northern Dominican Republic Gregorio Luperón metro station, a metro station in Santo Domingo Gregorio Luperón High School for Math & Science, a high school in New York City