Safo may refer to:
Balcha Safo (1863–1936), Ethiopian general Lucy Safo, Ghanaian writer Safo, Mali, a town and commune in the Koulikoro Region of Mali Safo, Niger, a village and rural commune in Niger Safo, historia de una pasión, a 1943 Argentine romantic drama film Sarah Adwoa Safo, a Ghanaian lawyer and politician Safo'63, ("Love and Sex (Sappho '63)"), a 1964 Mexican film Derek Andrew Safo (1982–2026), British-Ghanaian hip-hop artist known professionally as Sway Dasafo or Sway
See also SAFO, an information tool in the aviation community Sappho, ancient Greek poet